Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?
Identifieur interne : 002075 ( Main/Exploration ); précédent : 002074; suivant : 002076Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?
Auteurs : Tazzio Tissot [France] ; Beata Ujvari [Australie] ; Eric Solary [France] ; Patrice Lassus [France] ; Benjamin Roche [France] ; Frédéric Thomas [France]Source :
- Biochimica et biophysica acta [ 0006-3002 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Tumeurs.
- Humains, Microenvironnement tumoral, Mutation, Écosystème, Évolution de la maladie.
English descriptors
- KwdEn :
- MESH :
- pathology : Neoplasms.
- Disease Progression, Ecosystem, Humans, Mutation, Tumor Microenvironment.
Abstract
By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment.
DOI: 10.1016/j.bbcan.2016.01.005
PubMed: 26845682
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002065
- to stream PubMed, to step Curation: 002040
- to stream PubMed, to step Checkpoint: 002040
- to stream Ncbi, to step Merge: 003097
- to stream Ncbi, to step Curation: 003097
- to stream Ncbi, to step Checkpoint: 003097
- to stream Main, to step Merge: 002074
- to stream Main, to step Curation: 002075
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?</title><author><name sortKey="Tissot, Tazzio" sort="Tissot, Tazzio" uniqKey="Tissot T" first="Tazzio" last="Tissot">Tazzio Tissot</name><affiliation wicri:level="1"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France. Electronic address: tazziotissot@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5</wicri:regionArea><wicri:noRegion>34394 Montpellier Cedex 5</wicri:noRegion><wicri:noRegion>34394 Montpellier Cedex 5</wicri:noRegion></affiliation></author><author><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds</wicri:regionArea><wicri:noRegion>Waurn Ponds</wicri:noRegion></affiliation></author><author><name sortKey="Solary, Eric" sort="Solary, Eric" uniqKey="Solary E" first="Eric" last="Solary">Eric Solary</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U1170, Gustave Roussy, 94805 Villejuif, France; University Paris-Saclay, Faculty of Medicine, 94270 Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Gustave Roussy, 94805 Villejuif, France; University Paris-Saclay, Faculty of Medicine, 94270 Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>94270 Le Kremlin-Bicêtre</wicri:noRegion><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Le Kremlin-Bicêtre</settlement></placeName></affiliation></author><author><name sortKey="Lassus, Patrice" sort="Lassus, Patrice" uniqKey="Lassus P" first="Patrice" last="Lassus">Patrice Lassus</name><affiliation wicri:level="3"><nlm:affiliation>CNRS, UMR 5535, Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 5535, Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name><affiliation wicri:level="1"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France; Unité mixte internationale de Modélisation Mathématique et Informatique des Systèmes Complexes (UMI IRD/UPMC UMMISCO), 32 Avenue Henri Varagnat, 93143 Bondy Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France; Unité mixte internationale de Modélisation Mathématique et Informatique des Systèmes Complexes (UMI IRD/UPMC UMMISCO), 32 Avenue Henri Varagnat, 93143 Bondy Cedex</wicri:regionArea><wicri:noRegion>93143 Bondy Cedex</wicri:noRegion><wicri:noRegion>93143 Bondy Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name><affiliation wicri:level="1"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5</wicri:regionArea><wicri:noRegion>34394 Montpellier Cedex 5</wicri:noRegion><wicri:noRegion>34394 Montpellier Cedex 5</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26845682</idno><idno type="pmid">26845682</idno><idno type="doi">10.1016/j.bbcan.2016.01.005</idno><idno type="wicri:Area/PubMed/Corpus">002065</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002065</idno><idno type="wicri:Area/PubMed/Curation">002040</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002040</idno><idno type="wicri:Area/PubMed/Checkpoint">002040</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002040</idno><idno type="wicri:Area/Ncbi/Merge">003097</idno><idno type="wicri:Area/Ncbi/Curation">003097</idno><idno type="wicri:Area/Ncbi/Checkpoint">003097</idno><idno type="wicri:doubleKey">0006-3002:2016:Tissot T:do:cell:autonomous</idno><idno type="wicri:Area/Main/Merge">002074</idno><idno type="wicri:Area/Main/Curation">002075</idno><idno type="wicri:Area/Main/Exploration">002075</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?</title><author><name sortKey="Tissot, Tazzio" sort="Tissot, Tazzio" uniqKey="Tissot T" first="Tazzio" last="Tissot">Tazzio Tissot</name><affiliation wicri:level="3"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France. Electronic address: tazziotissot@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds</wicri:regionArea><wicri:noRegion>Waurn Ponds</wicri:noRegion></affiliation></author><author><name sortKey="Solary, Eric" sort="Solary, Eric" uniqKey="Solary E" first="Eric" last="Solary">Eric Solary</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1170, Gustave Roussy, 94805 Villejuif, France; University Paris-Saclay, Faculty of Medicine, 94270 Le Kremlin-Bicêtre, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1170, Gustave Roussy, 94805 Villejuif, France; University Paris-Saclay, Faculty of Medicine, 94270 Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>94270 Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>94270 Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Lassus, Patrice" sort="Lassus, Patrice" uniqKey="Lassus P" first="Patrice" last="Lassus">Patrice Lassus</name><affiliation wicri:level="3"><nlm:affiliation>CNRS, UMR 5535, Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR 5535, Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name><affiliation wicri:level="1"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France; Unité mixte internationale de Modélisation Mathématique et Informatique des Systèmes Complexes (UMI IRD/UPMC UMMISCO), 32 Avenue Henri Varagnat, 93143 Bondy Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France; Unité mixte internationale de Modélisation Mathématique et Informatique des Systèmes Complexes (UMI IRD/UPMC UMMISCO), 32 Avenue Henri Varagnat, 93143 Bondy Cedex</wicri:regionArea><wicri:noRegion>93143 Bondy Cedex</wicri:noRegion><wicri:noRegion>93143 Bondy Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name><affiliation wicri:level="1"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5</wicri:regionArea><wicri:noRegion>34394 Montpellier Cedex 5</wicri:noRegion><wicri:noRegion>34394 Montpellier Cedex 5</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochimica et biophysica acta</title><idno type="ISSN">0006-3002</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease Progression</term><term>Ecosystem</term><term>Humans</term><term>Mutation</term><term>Neoplasms (pathology)</term><term>Tumor Microenvironment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Microenvironnement tumoral</term><term>Mutation</term><term>Tumeurs (anatomopathologie)</term><term>Écosystème</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Disease Progression</term><term>Ecosystem</term><term>Humans</term><term>Mutation</term><term>Tumor Microenvironment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Microenvironnement tumoral</term><term>Mutation</term><term>Écosystème</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">By definition, a driver mutation confers a growth advantage to the cancer cell in which it occurs, while a passenger mutation does not: the former is usually considered as the engine of cancer progression, while the latter is not. Actually, the effects of a given mutation depend on the genetic background of the cell in which it appears, thus can differ in the subclones that form a tumor. In addition to cell-autonomous effects generated by the mutations, non-cell-autonomous effects shape the phenotype of a cancer cell. Here, we review the evidence that a network of biological interactions between subclones drives cancer cell adaptation and amplifies intra-tumor heterogeneity. Integrating the role of mutations in tumor ecosystems generates innovative strategies targeting the tumor ecosystem's weaknesses to improve cancer treatment.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Tissot, Tazzio" sort="Tissot, Tazzio" uniqKey="Tissot T" first="Tazzio" last="Tissot">Tazzio Tissot</name></region><name sortKey="Lassus, Patrice" sort="Lassus, Patrice" uniqKey="Lassus P" first="Patrice" last="Lassus">Patrice Lassus</name><name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name><name sortKey="Solary, Eric" sort="Solary, Eric" uniqKey="Solary E" first="Eric" last="Solary">Eric Solary</name><name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name></country><country name="Australie"><noRegion><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002075 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002075 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26845682
|texte= Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26845682" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |